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Behind ‘No Kings’ St. Paul protest: $250K production machine equal to a Def Leppard concert

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When anti-Trump protesters took to the streets across the country in late March for rallies branded as «No Kings,» CNN reported that anti-Trump protests had «popped up» nationwide, including at the Minnesota State Capitol.

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But a Fox News Digital investigation reveals that nine vendors were paid an estimated $250,000 to build a professionally-sophisticated protest infrastructure behind the «flagship» event held in St. Paul, and a former Obama and Biden administration political and communications strategist, Roger Fisk, took credit for being the «Senior Advisor to the #NoKings flagship event,» fine-tuning the «art and science» of throwing the protest, along with two other «No Kings» protests last year.

The machine behind the protest included deploying about 30 semi-trucks to deliver concert-level equipment, a massive mobile stage, nearly a mile of heavy-duty feeder cable used to distribute electricity throughout the rally site, scores of porta-toilets and folding chairs, eight jumbo screens, high-speed internet and bike-rack barriers to keep the crowds away from the stage, filled with bold-faced celebrities including rock star Bruce Springsteen, actress Jane Fonda and singer Joan Baez. 

The operation amounted to a massive buildout that resembled the setup for an outdoor music festival or Def Leppard concert, according to the event’s vendors, most of whom requested anonymity.

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The logistical details behind the event illustrate how modern protests increasingly resemble professionally produced public events rather than spontaneous grassroots demonstrations. The investigation reveals a rare behind-the-scenes view of the infrastructure, funding and logistics that power the modern day protest industry, details organizers rarely disclose.

500 GROUPS WITH $3B IN REVENUES ARE BEHIND THE #NOKINGS PROTESTS AND COMMUNIST CALL FOR ‘REVOLUTION’

Professional vendors supplied the bike-rack barriers, tents and jumbo video screens at the No Kings protest on March 28, 2026, in St. Paul, Minn., outside the State Capitol. (Stephen Maturen/Getty Images)

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As Fox News Digital previously reported, about 500 organizations with an estimated $3 billion in annual revenues sponsored, endorsed and participated in the nationwide protest. The network includes stalwart Democratic nonprofits including Indivisible, MoveOn and the ACLU, which have received millions of dollars over the years from billionaire George Soros and his Open Society philanthropies.

Another network tied to the protests includes pro-communist groups, like the People’s Forum, CodePink, the ANSWER Coalition and the Party for Socialism and Liberation, backed by American-born tech tycoon Neville Roy Singham, who lives in Shanghai, promoting messaging aligned with the Chinese Communist Party, President Xi Jinping and the People’s Republic of China. Notably, anti-American rhetoric from China labeling the United States as «fascist,» «rogue,» and «autocratic» has been parroted by these groups and surfaced as a recurring theme in the St. Paul protest, where communist and socialist organizations flew the flags of Iran, Venezuela and Cuba. Singham didn’t respond to a request for comment.

POWER COUPLE OF CHAOS: HOW A TYCOON AND ACTIVIST BUILT A ‘REVOLUTIONARY BASE’ AT THE HOUSE OF SINGHAM

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Protesters gathering with flags and signs in front of the Minnesota State Capitol building

A variety of international flags are hoisted by demonstrators at the Minnesota State Capitol in St. Paul on March 28, 2026. (Derek Shook for Fox News Digital)

It’s understood that Indivisible footed most of the bill for the St. Paul protest, sources said.

Nancy Snow, author of the book, «Propaganda and Persuasion,» told Fox News Digital that it’s important to follow the money on all aspects of political communication, including protests.

«We are in an age of cognitive warfare, in which there is a competition to shape how people think, and it’s always important to follow the money because it tells you who is setting the agenda and amplifying the message,» she said. «Following the money doesn’t automatically invalidate the grievances of citizens who show up for a protest. Both things can be true at once.»

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About 24 hours before demonstrators arrived with signs calling the U.S. a «fascist» nation, a different scene unfolded on the Capitol grounds, with semi-trucks loaded with equipment rolling into the State Capitol.

NO KINGS’ CALLS ITSELF LEADERLESS, BUT ITS OWN INTERNAL DOCUMENTS TELL A VERY DIFFERENT STORY

Professional vendors at the No Kings protest on March 28, 2026, in St. Paul, Minn.

Matt Svobodny, production manager at Slamhammer Sound & Roadcase Co. stands in front of the stage that he and his crew set up for the «No Kings» protest in St. Paul, Minn. (Fox News Digital)

«You need a platform for people to stand on and a way for people to be seen and heard in order to reach everybody,» Matt Svobodny, a production manager with Slamhammer Sound & Roadcase Co., a live-event production company based in nearby St. Louis Park, Minn., told Fox News Digital. 

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«And, in order to do that, you need professionals that know what they’re doing and are going to do it also safe for all the people…,» he said. «So you can’t just have people with good intentions and no idea what they’re doing.»

A longtime professional, Svobodny provided a rare warehouse tour of the elements required to make the protest happen.

Svobodny said crews began physical setup around 8 a.m. Friday and continued working until after midnight, returning in early morning. Along with the mobile concert stage and cable, the system they assembled included about 100 speakers and extensive lighting equipment. Three vendors supplied eight large video screens across the Capitol grounds so people far from the stage at the far end near Martin Luther King Boulevard could see the speakers.

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Additional delay speakers were positioned farther back from the stage so that speeches would remain synchronized across the large audience area, he said. For security reasons, the stage was partially fitted with ballistic bullet-resistant glass to protect the speakers.

«It has all the elements and infrastructure of a music festival,» Svobodny said.

Permit records, obtained by Fox News Digital, identify the organizing entity for the event as the «No Kings Coalition and Indivisible Twin Cities.» Indivisible is the brand name for several powerful Democratic groups: Indivisible Action, a political action committee; Indivisible Project, a 501(c)(4) with $10.4 million in revenues; and Indivisible Action, a 501(c)(3) with $5.2 million in revenues.

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The permit application listed a local leader, Kris Ragozzino, as the applicant and described the rally as a program including «speakers, artists and musicians.» The production itself relied on a network of specialized vendors, each responsible for a different component of the rally’s infrastructure. 

  1. Slamhammer Sound & Roadcase Co., based in St. Louis Park, Minn., was the main event vendor, handling the Stageline SL320 40-foot mobile stage, sound system with 100 speakers, lighting, 1,700-feet of 220-volt feeder cable and ballistic bullet-resistant barriers, while coordinating the overall production setup and contracting with subvendors. Estimated cost: $100,000
  2. Fire Up Video supplied four large video screens placed along Martin Luther King Boulevard at the far end away from the protest. Estimated cost: $20,000
  3. Algorithm, an audiovisual production company based in Minnesota, provided two additional jumbo screens positioned on the sides of the rally. On its Instagram page, Algorithm featured its screens, hauled to the protest by massive trucks, in a video from the day with the message, «Can you feel it?» Estimated cost: $25,000
  4. Common World Productions Inc. provided two more LED jumbo video screens mounted directly on the stage. Estimated cost: $10,000
  5. Warning Lites of Minnesota, a Minneapolis company that provides traffic control and event safety equipment, supplied crowd-control bike-rack barricades separating the stage from the crowd. Estimated cost: $15,000
  6. E5 Energy, based in Savage, Minn., provided electrical power to the stage and screens with generators and distribution equipment. It also installed cable ramps to cover the high-voltage power lines as pedestrians crossed over them. Estimated cost: $15,000
  7. Ultimate Events, based in Plymouth, Minn., supplied an estimated 10 large high-peak tents for staging areas and operations. It also provided «black plastic frame folding chairs,» typically priced at $2.80 per chair on its website, and tables. Estimated cost: $30,000
  8. On Site Companies, based in St. Paul, provided about 300 porta-toilets. Estimated cost: $25,000
  9. Fast Kat Connects, based in Minneapolis, provided high-speed internet connection for the organizers. Estimated cost: $10,000

The estimated total for the logistical expenses was $250,000, sources said.

Former Obama and Biden administration advance man Roger Fisk poses for a photo.

PR expert Roger Fisk poses for a profile shoot during FICCI Frames 2014 on March 20, 2014, in Mumbai, India. He has been described as a political campaign, marketing and media strategist credited with playing a key behind-the-scenes role in Barack Obama’s presidential wins in 2008 and 2012. He also worked in the Biden administration. He is now a self-described «Senior Advisor» with Indivisible, organizing its «No Kings» protests. ( (PhAbhijit Bhatlekar/Mint via Getty Images)

Svobodny said he worked mostly with Ragozzino and Roger Fisk, a former advance man for presidential trips in the Obama and Biden administrations. In a post on LinkedIn after the protest, Fisk described himself as a «Senior Advisor to the #NoKings flagship event.» 

In the post, Fisk recalled the «complexity» of organizing the event, noting, «Add to that satellite trucks, cable runs, ballistic glass, road closures, most of the bike rack [sic] in North America, risk monitoring and threat analysis, bridge construction, Springsteen, a kaleidoscope of law enforcement, and staffs of elected officials, security details, and other celebrities that require specific care and respect. The final week was 4 am to 9-10-11 pm…»

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Professional vendors at the No Kings protest on March 28, 2026, in St. Paul, Minn.

E5 Energy supplied the generators and electricity to power the «No Kings» protest in St. Paul, Minn. Ultimate Events provided the canvas tents. (Asra Q. Nomani/Fox News Digital)

Fisk added that «we have learned so much together in developing the art and science of these massive pro-democracy public engagements.» Ragozzino, Fisk and Indivisible co-founders Ezra Levin and Leah Greenberg didn’t respond to requests for comment.

Fisk bluntly acknowledged the protests were staged for the cameras for maximum media coverage, which public relations officials call «earned media,» a buzzword for free press coverage. «Earned media is my main metric,» Fisk wrote, «and our content reached between a quarter and a half billion impressions in the 24 hours after the events, with our flagship event leading the way.»

In his LinkedIn profile, Fisk writes that he worked this past year as a consultant to  Indivisible and its three earlier «No Kings» protests, saying he «developed thematic strategies and program frameworks for Indivisible’s three pro-democracy mobilizations, engaging 15 million people across every state and 22 countries coordinating messaging across messaging networks.» He didn’t disclose how much he had been paid.

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COMMUNISTS, DEMOCRATS USE #NOKINGS RALLY TO CALL FOR MAY DAY STRIKE: ‘SHUT IT DOWN’

Snow, the former director of the New Hampshire chapter of Common Cause, a progressive group, said that «sunshine is the best disinfectant» and encourages organizations to be more transparent about the obvious logistical heavy-lifting it takes to throw a protest.

In his company’s warehouse, as crews cleaned the stage, Svobodny considered the event a success, in part because the vendors went unnoticed by the media. «Hopefully, most people didn’t even think about us,» he said. 

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«I mean, in some ways, kind of, the goal of us or myself is to, like, not even be noticed.»

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Hannah Brennan contributed to this report.

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Fuerzas especiales en el territorio y apoyo de la CIA: así fue el peligroso operativo para rescatar a un piloto estadounidense de Irán

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Comandos estadounidenses se desplegaron en lo profundo del territorio iraní para rescatar a un piloto de un caza F-15 derribado, en un operativo que incluyó operaciones de inteligencia de la CIA y la ayuda de Israel. Lo informaron este domingo medios estadounidenses e israelíes.

El presidente Donald Trump anunció que el militar fue recuperado con vida, aunque admitió que se encuentra “gravemente herido”.

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Teherán dijo esta semana que había derribado un caza F-15, el primer avión de combate estadounidense abatido en Irán desde el inicio de la guerra. Washington no confirmó los detalles del hecho.

Uno de los dos tripulantes del caza fue rescatado poco después del incidente, pero el otro seguía desaparecido, lo que llevó a Trump a ordenar una operación de búsqueda y rescate en combate (CSAR).

“Uno de los rescates más audaces de la historia”

Trump declaró a primera hora del domingo que el ejército había “llevado a cabo una de las operaciones de búsqueda y rescate más audaces de la historia de Estados Unidos, en favor de uno de nuestros increíbles oficiales de la tripulación, quien, además, resulta ser un coronel sumamente respetado, y de quien me entusiasma comunicarles que ya se encuentra SANO y SALVO”.

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En un mensaje posterior describió la misión de rescate como “una muestra increíble de valentía y talento por parte de todos”.

El presidente Donald Trump en una exposición sobre la guerra con Irán, desde el Salón de la Cruz de la Casa Blanca. (Foto AP – Alex Brandon – Pool)

Cómo fue el rescate

Los comandos del Equipo 6 de los Navy SEAL (la principal fuerza de operaciones especiales de la Armada estadounidense) recibieron la misión de extraer al aviador, mientras que aviones de ataque lanzaban bombas y abrían fuego contra convoyes iraníes para mantenerlos a distancia, informó una fuente citada por The New York Times.

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Aunque resultó herido, el aviador, un oficial de sistemas de armas, podía caminar y logró evadir la captura en las montañas durante más de un día, según el medio de noticias Axios, que citó a un funcionario estadounidense.

Leé también: León XIV celebró su primera misa de Pascua como papa y lanzó una advertencia sobre la guerra en Medio Oriente

El piloto no identificado estaba equipado con una pistola, una baliza y un dispositivo de comunicaciones seguras para coordinarse con los rescatistas, señaló The New York Times.

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Según explicó un funcionario del Gobierno a The Washington Post, el militar permaneció escondido en una grieta de una montaña para evitar a las fuerzas iraníes que se acercaban para capturarle.

Sufrió algunas lesiones, pero según informó la BBC, pudo escapar por sus propios medios.

Los comandos estadounidenses que convergían hacia el oficial dispararon sus armas para mantener a las fuerzas iraníes alejadas del lugar del rescate, agregó. Según Teherán, cinco personas murieron en el ataque.

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“Tras el ataque estadounidense-sionista de anoche contra las alturas de Kuh-e Siah, en Kohgiluyeh, cinco personas murieron y siete resultaron heridas”, anunció el gobierno de la provincia de Kohgiluyeh y Boyer Ahmad, informó la agencia Tasnim, vinculada a la Guardia Revolucionaria iraní.

En tanto, Trump aclaró que el piloto “sufrió heridas, pero estará perfectamente bien”. Sin embargo, su segunda publicación afirmó que el aviador había resultado “gravemente herido”, sin ofrecer más detalles.

Un caza F15similar al derribado por Irán (Foto: REUTERS/Athit Perawongmetha)

Un caza F15similar al derribado por Irán (Foto: REUTERS/Athit Perawongmetha)

Una operación compleja

La carrera por ver quién llegaba primero al militar desaparecido recrudeció después de que la televisión iraní ofreció una recompensa a quien lo encontrara, mientras que sus fuerzas salían en su búsqueda.

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Además, dos de los aviones estadounidenses destinados a trasladar al aviador y a sus rescatistas a un lugar seguro quedaron inmovilizados en una base remota en Irán y tuvieron que ser destruidos para evitar que cayeran en manos iraníes, informaron The New York Times y CBS.

Las fuerzas estadounidenses utilizaron entonces otros tres aviones de transporte para sacar al aviador y a sus rescatistas de Irán.

El ejército iraní afirmó el domingo que la operación estadounidense para rescatar al aviador había utilizado un aeropuerto abandonado en la provincia meridional de Isfahán.

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Ebrahim Zolfaghari, portavoz del mando central de las fuerzas armadas iraníes, declaró que dos aviones de transporte militar estadounidenses C-130 y dos helicópteros Black Hawk fueron destruidos.

Leé también: Zanjas, drones e inspecciones laborales: cómo es el “Plan Escudo Fronterizo” que lanzó Kast en Chile

Campaña de engaños

Según informes, la CIA difundió una campaña de engaños dentro de Irán con versiones de que las fuerzas estadounidenses estaban sacando al aviador del país por vía terrestre.

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Fue la CIA quien localizó al piloto y compartió su ubicación con la Casa Blanca para que Trump ordenara la misión de rescate, dijo EFE. La prensa israelí dijo que la inteligencia de su país también contribuyó en la acción.

Las labores de búsqueda estuvieron marcadas por fuego cruzado entre los helicópteros estadounidenses desplazados y los iraníes que se encontraban en tierra.

El Pentágono desplegó aviones C-130, helicópteros de rescate y decenas de aeronaves que volaban con perfil bajo y lento, a muy baja cota para evitar radares y bajo la amenaza de ser derribados.

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Irán aseguró hoy que durante esta operación derribó cuatro aeronaves estadounidenses.

(Con información de AFP y EFE)

Irán, Estados Unidos, Donald Trump

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GOP races to pass ICE, Border Patrol funding bill as priorities pile up, divisions emerge

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A party-line tactic to ram legislation through Congress and bypass the Senate filibuster has become a dumping ground for Republicans’ legislative priorities throughout the year.

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Now, as Democrats refuse to fund immigration operations, Republicans are once again readying a budget reconciliation package. The hard part will be getting enough of the GOP on the same page to craft a bill that can pass and survive the strict rules underpinning the process.

Republicans used the same process to pass President Donald Trump’s «big, beautiful bill» last year. It’s a time-consuming, labor-intensive legislative maneuver that nearly blew up and could fail unless both the Senate and House align on what exactly they want to include.

SENATE PASSES BILL TO FUND MOST OF DHS AFTER HOUSE GOP CAVES

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President Donald Trump answers questions from reporters after signing an executive order in the Oval Office of the White House Tuesday, March 31, 2026, in Washington. (Alex Brandon/AP Photo)

Trump officially backed using reconciliation again this week as a way to skirt Democrats’ refusal to fund Immigration and Customs Enforcement (ICE) and Customs and Border Protection (CBP), as Congress inches closer to ending the ongoing Department of Homeland Security (DHS) shutdown.

Trump demanded that Republicans get the bill on his desk by June 1.

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«We are going to work as fast and as focused as possible to replenish funding for our Border and ICE agents, and the Radical Left Democrats won’t be able to stop us,» Trump said on Truth Social.

Still, Republicans have viewed reconciliation as a vehicle to tackle fraud, affordability, Trump’s tariff authorities, additional tax provisions, healthcare, funding for the Iran war, supplemental agriculture spending and election integrity measures in the months since passing the «big, beautiful bill.»

DHS SHUTDOWN BREAKTHROUGH COMES AT COST FOR REPUBLICANS AS FUNDING FIGHTS NEARS END

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Senate Majority Leader John Thune, R-S.D.

Senate Majority Leader John Thune, R-S.D., said Republicans need to «keep our expectations realistic.» (Stefani Reynolds/Bloomberg via Getty Images)

Senate Majority Leader John Thune, R-S.D., has warned that if reconciliation is going to work — especially given the limited timeframe lawmakers have to start and finish the process — Republicans need to «keep our expectations realistic.»

«Our theory of the case behind all this was to keep that thing as narrow and focused as possible, and that maximizes the speed at which we can do it and the support for it,» Thune said.

«There will probably be some attempts to add things,» he continued. «There are things out there that, obviously, many of us are interested in. But on a reconciliation vehicle like this — which we need to move with haste, as the president has pointed out — it’s probably not a likely magnet for all these other issues.»

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Senate Budget Committee Chair Lindsey Graham, R-S.C., told voters at an event this week in South Carolina that he is eyeing two new reconciliation packages, which could ease concerns about cramming all the GOP’s priorities into one massive bill.

GOP RAILS AGAINST ‘S— SANDWICH’ DEAL AS ALL EYES TURN TO HOUSE TO END DHS SHUTDOWN

Lindsey Graham walking through a hallway toward the chamber.

Sen. Lindsey Graham, R-S.C., walks to the Senate chamber for votes after meeting behind closed doors with fellow Republicans on the Homeland Security budget stalemate, at the Capitol in Washington, March 26, 2026. (J. Scott Applewhite/AP Photo)

«We want to do it quick — ICE, Border Patrol — fund it as much as you can, multi-year,» Graham said. «Then there’s another one coming. I just made news. There’s another one coming in the fall, and that’s going to be about going after fraud.»

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House Republicans spent their recent policy retreat earlier this year pushing a so-called «reconciliation 2.0,» gearing up to load the package with several provisions that could drain time and struggle to earn support in the Senate — where strict guidelines could kill proposals entirely if they don’t comply with the rules.

The Republican Study Committee (RSC), which has long called for a second reconciliation bill, also wants to add proposals addressing affordability concerns.

«We support pursuing funding for military readiness and Homeland Security through this legislative process, while simultaneously codifying the president’s agenda to deliver lower costs for working families,» the RSC Steering Committee said in a statement to Fox News Digital.

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Some Republicans are also pushing to include the latest policy fight: the Safeguarding American Voter Eligibility (SAVE) Act. The voter ID and citizenship verification legislation has no chance of passing the Senate given unified Democratic opposition.

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It’s also unlikely to survive the Senate’s reconciliation rules, which allow only provisions that directly impact spending.

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«I think we have to set our sights a little bit lower on this reconciliation bill,» Sen. Roger Marshall, R-Kan., told Fox News Digital. «It’s got to be targeted to fund ICE for 10 years — I think that’s the number one thing for us. If we can nibble at the edges of the SAVE Act, that would be great, but the parliamentarian is not going to let us do the SAVE Act. That’s just an impossibility.»

Some of the loudest proponents of the bill in the House GOP acknowledge that adding the SAVE Act to reconciliation would be a challenge — largely because they would prefer to keep the bill intact and push it through the Senate.

«Look, it’s time for them to do a walk-and-talk and filibuster, and let’s make this thing happen,» Rep. Ralph Norman, R-S.C., said. «The American people are watching — piecing it together just to try to get a piece.»

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Un medicamento para la diabetes podría ayudar a controlar el peso en hombres con cáncer de próstata

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Investigadores del Sylvester Comprehensive Cancer Center de Miami estudian el efecto de la metformina en pacientes con cáncer de próstata./Archivo

La metformina es un medicamento utilizado principalmente para tratar la diabetes tipo 2 que ayuda a controlar los niveles de glucosa en sangre.

Científicos de los Estados Unidos identificaron que se le podría dar otro uso al medicamento también. En hombres con cáncer de próstata, el fármaco podría producir un efecto similar al que genera el ejercicio intenso en el cuerpo.

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Es porque la metformina eleva los niveles de una molécula clave para el equilibrio energético y el peso, aun cuando los pacientes no realizan actividad física.

El trabajo fue realizado por investigadores del Sylvester Comprehensive Cancer Center, en Miami, un centro especializado en cáncer. Lo publicaron en la revista científica EMBO Molecular Medicine.

Qué motivó a hacer el estudio

(Imagen Ilustrativa Infobae)
El medicamento metformina podría imitar en el cuerpo los efectos metabólicos del ejercicio intenso sin necesidad de actividad física. (Imagen Ilustrativa Infobae)

Muchos de los pacientes con cáncer de próstata sienten fatiga, dolores o presentan limitaciones físicas que hacen difícil mantener una rutina de ejercicios.

La terapia hormonal, utilizada para combatir el cáncer de próstata, puede alterar el metabolismo y provocar aumento de peso, resistencia a la insulina y riesgo cardiovascular.

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Por eso, los científicos buscaron alternativas para ayudar a quienes no pueden moverse con facilidad durante el tratamiento.

Nuevo tratamiento elimina el cáncer de vejiga en 82 % de pacientes
El uso de la metformina resulta especialmente relevante para pacientes con cáncer de próstata que no pueden realizar ejercicio por fatiga o dolor (Freepik)

El medicamento logró aumentar los niveles de N-lactoil-fenilalanina (Lac-Phe), una molécula que el cuerpo fabrica cuando necesita más energía.

Lac-Phe aparece cuando el lactato, que se produce al hacer esfuerzo, se une a la fenilalanina, un aminoácido que forma parte de las proteínas.

Estudios previos en animales y humanos ya habían relacionado altos niveles de Lac-Phe con menor apetito y mejor control del peso.

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Señales del cuerpo, caminos de la medicina

Los investigadores observaron que la metformina elevó Lac-Phe en pacientes sin actividad física, y que los valores alcanzados eran parecidos a los que se ven luego de una sesión exigente de ejercicios.

(Imagen Ilustrativa Infobae)
La metformina logra aumentar los niveles de la molécula Lac-Phe, vinculada a la regulación energética y el control del peso (Imagen Ilustrativa Infobae)

Este dato llamó la atención porque muestra que ciertas rutas metabólicas pueden activarse incluso cuando no hay movimiento.

El estudio aclara que tomar metformina no reemplaza los beneficios del ejercicio físico, pero ayuda a entender cómo funcionan los mecanismos internos del metabolismo.

El objetivo es explorar si existen formas de proteger la salud metabólica en pacientes que no pueden hacer ejercicio debido a los tratamientos o a otros problemas.

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La investigación también comprobó que los niveles de Lac-Phe elevados por la metformina no se vincularon con cambios en el antígeno prostático específico (PSA), el análisis de sangre que se usa para seguir la evolución del cáncer de próstata.

Esto significa que, aunque la molécula se relaciona con el metabolismo y el peso, no afecta directamente al tumor.

Metformina, una aliada inesperada

Primer plano de piernas entrenadas y tonificadas con piel bronceada y venas visibles, vistiendo shorts negros y zapatillas deportivas negras en un gimnasio.
El estudio muestra que algunos beneficios metabólicos del ejercicio pueden activarse con un medicamento en personas que no pueden moverse. (Imagen Ilustrativa Infobae)

Además de Lac-Phe, la metformina elevó otra sustancia llamada GDF-15, aunque la relación de esta molécula con los cambios de peso fue menos clara.

El equipo dirigido por Marijo Bilusic, oncólogo y profesor en la Universidad de Miami, señaló que la combinación del trabajo de laboratorio y estudios clínicos permitió unir los resultados moleculares con datos de pacientes reales.

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La doctora Priyamvada Rai, experta en biología tumoral, explicó que mantener la salud metabólica puede ser clave para que los pacientes toleren mejor los tratamientos y se sientan mejor en su vida diaria.

En tanto, el profesor David Lombard, del área de epigenética, agregó que estudiar el metabolismo celular ayuda a comprender el impacto de la metformina en personas con cáncer de próstata.

laboratorio ciencia investigacion cientifica microscopio (freepik)
La investigación abre nuevas perspectivas sobre cómo la metformina puede apoyar la salud metabólica en pacientes con movilidad reducida por el cáncer./Freepik

Los resultados se confirmaron en distintos contextos clínicos y también en pacientes tratados con otras terapias metabólicas.

Esto sugiere que Lac-Phe podría reflejar un ajuste más amplio del metabolismo, no solo un efecto exclusivo de la metformina.

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La potencial utilidad de la metformina en pacientes con cáncer de próstata abre una nueva línea de investigación sobre cómo los medicamentos pueden apoyar el metabolismo cuando la actividad física no es posible o resulta muy difícil.



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