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Succeeding Trump: 6 Republican potential presidential hopefuls to keep your eyes on in 2028
Will JD Vance and AOC face off in 2028?
The ‘All-Star’ panelists Matthew Continetti, Sabrina Singh and Philip Wegmann take a look at early speculation about the 2028 White House race and more on ‘Special Report.’
The 2028 presidential election seems like a long way away, but in reality, the early moves are already underway by some Democrats with likely national ambitions.
And one Republican politician is already selling 2028 merchandise.
«Trump 2028» hats are available for $50 and T-shirts that read, «Trump 2028 (Re-write the Rules),» sell for $36 on the Trump Organization’s website.
But the rules are quite clear: The 22nd Amendment to the U.S. Constitution restricts presidents to two terms in office.
And after months of flirting with running for a third term in the White House, President Donald Trump appears to be ruling out another campaign.
WHERE TRUMP STANDS WITH AMERICANS 4 MONTHS INTO HIS 2ND TERM
President Donald Trump, shown delivering the commencement address at the U.S. Military Academy graduation ceremony at West Point, New York, on May 24, 2025, seemed to rule out running for a third term in a recent interview. (Saul Loeb/AFP via Getty Images)
Despite touting strong support in the MAGA world for a 2028 run for re-election, the president in an interview this month on NBC News’ «Meet the Press» said, «I’m not looking at that.»
«I’ll be an eight-year president,» Trump added. «I’ll be a two-term president. I always thought that was very important.»
But Trump’s 2028 flirtations, which he said weren’t a joke, and his sweeping moves since the start of his second tour of duty in the White House are keeping the spotlight firmly on him, averting any lame-duck talk and putting a damper on any early moves by those in the Republican Party hoping to succeed the president.
DEMOCRATS EYE 2028 JUST MONTHS INTO TRUMP’S 2ND TERM
The race for the next GOP presidential nomination won’t get underway until Trump’s ready to share the spotlight, and he recently said it’s «far too early» to begin holding those discussions.
But Trump also added, «I’m looking to have four great years and turn it over to somebody, ideally a great Republican, a great Republican to carry it forward.»
With that in mind, here’s a look at the potential 2028 Republican White House contenders.
Vice President JD Vance
Vice President JD Vance (Stephanie Scarbrough/Associated Press)
Vice President JD Vance appears to be the heir apparent to the «America First» movement and the Republican Party’s powerful MAGA base. It was a point driven home by Donald Trump Jr., the president’s eldest son, MAGA rockstar and powerful ally of the vice president.
«We are getting four more years of Trump and then eight years of JD Vance,» Trump Jr. said on the campaign trail in Ohio a few weeks ahead of the November 2024 election.
As sitting vice president, Vance enjoys plenty of perks that could boost him to frontrunner status. Among them, a large staff that comes with the job, and Air Force Two, which he has repeatedly used to make stops across the U.S. and the globe since the start of the second Trump administration.
And Vance is now finance chair of the Republican National Committee, the first sitting vice president to hold such a position with a national party committee. The posting puts Vance in frequent contact with the GOP’s top donors.
But while Trump has hinted that Vance could be his successor and called him «a fantastic, brilliant guy» in the «Meet the Press» interview, he has avoided anointing his vice president as the party’s next nominee.
Vance has taken no steps toward a 2028 presidential run and isn’t seriously thinking about it at this time, a source in the vice president’s political orbit told Fox News.
«I really am just not focused on politics,» Vance said in early April in a «Fox and Friends» interview. «I’m not focused on the midterm elections in 2026, much less the presidential election in 2028. When we get to that point, I’ll talk to the president. We’ll figure out what we want to do.»
And the 40-year-old vice president added, «The way I think about it is, if we do a good job, the politics take care of themselves.»
Secretary of State Marco Rubio
Secretary of State Marco Rubio (Yuri Gripas/Abaca/Bloomberg via Getty Images)
In his «Meet the Press» interview, besides Vance, Trump also named Secretary of State Marco Rubio as a «great» potential GOP leader.
«Marco’s doing an outstanding job,» the president said.
Rubio, a one-time rival who clashed with Trump during the combustible 2016 Republican presidential nomination battle, became a leading Trump ally in the U.S. Senate during the president’s first term in office.
And besides serving as secretary of state, the 53-year-old former senator from Florida is also acting national security advisor, acting head of the National Archives and acting administrator of the U.S. Agency for International Development.
While Rubio’s expanding portfolio in the second Trump administration is fueling speculation about a potential 2028 presidential bid, he still faces skepticism from parts of MAGA world who question his «America First» credentials.
Florida Gov Ron DeSantis
Florida Gov. Ron DeSantis (Joe Raedle/Getty Images)
Conservative Florida Gov. Ron DeSantis was flying high after a landslide re-election in 2022, but an unsuccessful 2024 presidential primary run and a bruising battle with Trump knocked him down in stature.
However, the term-limited 46-year-old governor, who has a year and a half left in office steering Florida, proved in the past few years his fundraising prowess and retains plenty of supporters across the country.
DeSantis was also able, to a degree, to repair relations with Trump, helped raise money for the GOP ticket during the general election and earned a prime-time speaking slot at the 2024 Republican convention. And in December 2024, the governor was seen as a possible replacement when now-Defense Secretary Pete Hegseth’s nomination briefly faltered.
While DeSantis is certain to still harbor national ambitions, his feud this year with the Republican-dominated Florida legislature and the controversy over a charity tied to Florida first lady Casey DeSantis are seen as potential hurdles.
Virginia Gov Glenn Youngkin
Virginia Gov. Glenn Youngkin (Fox News – Paul Steinhauser)
Thanks to his 2021 gubernatorial victory, the first by a Republican in Virginia in a dozen years, Gov. Glenn Youngkin instantly became a GOP rising star.
In Virginia, governors are limited to one four-year term, which means Youngkin has seven months left in office.
The 58-year-old governor, who hails from the Republican Party’s business wing but has been able to thrive in a MAGA-dominated party, likely harbors national ambitions.
And Youngkin’s trip to Iowa, the state that for a half century has kicked off the GOP’s presidential nominating calendar, in July to headline a state party fundraising gala is sparking 2028 speculation.
Asked in late 2024 in a Fox News Digital interview about a White House run, Youngkin pointed to his job as governor, saying, «I need to finish strong so Virginia can really continue to soar. And that’s what I’m going to spend my time on.»
After that, he said, «We’ll see what’s next.»
Georgia Gov Brian Kemp
Georgia Gov. Brian Kemp (Fox News – Paul Steinhauser)
The popular conservative governor is one of the few in the GOP who can claim he faced Trump’s wrath and not only survived, but thrived.
Georgia Gov. Brian Kemp, who is term-limited, has two years left in office and enjoys strong favorable ratings in a crucial battleground state.
Kemp was heavily recruited by national Republicans to run in 2026 to try and flip a Democrat-controlled Senate seat. And the announcement earlier in May by the 61-year-old governor that he would pass on a 2026 Senate run, fueled buzz that Kemp may instead be mulling a 2028 White House run.
Asked in November 2024 about a potential presidential run, Kemp told Fox News Digital, «I try to keep all doors open in politics.»
Sen Ted Cruz
Republican Sen. Ted Cruz (Fox News – Paul Steinhauser)
Sen. Ted Cruz was the runner-up to Trump in the blockbuster 2016 Republican presidential battle.
The controversial conservative firebrand passed on challenging Trump again in 2024 as he ran for what was thought to be another difficult re-election bid after narrowly surviving his 2018 re-election.
However, the 54-year-old senator ended up winning a third six-year term in the Senate by nearly nine points.
Since the start of Trump’s second administration, Cruz has reaffirmed his conservative credentials by voicing opposition to the president’s controversial tariffs.
Honorable mentions
Among the others to keep an eye on is Nikki Haley.
The former two-term South Carolina governor, who served as U.N. ambassador in Trump’s first term, was the first GOP challenger to jump into the race against the former president in the 2024 nomination race.
Haley outlasted the rest of the field, becoming the final challenger to Trump before ending her White House bid in March 2024.
While the 53-year-old Haley ended up backing Trump in the general election, her earlier clashes with the president during the primaries left their mark. Even though she addressed the GOP faithful at the 2024 convention, her political future in a party dominated by Trump is uncertain.
Also, not to be discounted are three politicians who considered but passed on 2024 runs: Sens. Tom Cotton of Arkansas and Josh Hawley of Missouri and Homeland Security Secretary Kristi Noem.
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And besides Haley, we’ll put three other 2024 candidates on the large list of possible 2028 contenders. Businessman Vivek Ramaswamy is the Republican frontrunner in the 2026 campaign for Ohio governor but likely still has strong national ambitions.
Interior Secretary Doug Burgum is a very visible player in Trump’s Cabinet.
And former Vice President Mike Pence, when asked earlier this month by Fox News Digital if he might consider another White House run, reiterated that he intends to «be a voice» for traditional and conservative values and «we’ll let the future take care of itself.»
Donald Trump,JD Vance,Marco Rubio,Ron DeSantis,Brian Kemp,Republicans,Presidential Primaries,Elections,Politics
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Los niños llegan a un nuevo día de clases en Nueva Delhi, el 24 de noviembre de 2025. (Anindito Mukherjee/The New York Times)10:30 am, afuera de un hospital público
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Peatones, vendedores y rickshaws de bicicletas se mueven por una zona comercial al anochecer en Nueva Delhi, el 24 de noviembre de 2025. (Anindito Mukherjee/The New York Times)20:00 horas, en la estación de autobuses de Anand Vihar
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The Republican-controlled Indiana House returns to session on Monday to take action on congressional redistricting pushed by President Donald Trump.
And the GOP-dominated state Senate, in a major reversal, will reconvene in one week to «make a final decision on any redistricting proposal sent from the House.»
The proposed new map would create another GOP-leaning congressional district in the solidly Republican Midwestern state.
Indiana is the latest battlefield in the high-stakes redistricting showdown pitting Trump and Republicans versus Democrats to shape the 2026 midterm landscape as the GOP defends its razor-thin House majority.
TRUMP TURNS UP HEAT ON FELLOW REPUBLICANS IN PUSH TO REDRAW CONGRESSIONAL MAPS AHEAD OF MIDTERMS
The Indiana legislature on Monday returns to the Statehouse, seen in a file photo from 2017, to consider a congressional redistricting plan pushed by President Donald Trump. (AP Photo/Michael Conroy, File)
State House Speaker Todd Huston announced last week that «House Republicans will gavel in on Monday, Dec. 1, reconvening the 2026 regular session. All legislative business will be considered beginning next week, including redrawing the state’s congressional map.»
Despite pressure from Trump and his political team, Rodric Bray, the Republican leader in the Indiana Senate, announced two weeks ago that there wasn’t enough support in the chamber to move forward with redistricting.
DEEP-POCKETED CONSERVATIVE GROUP ‘ALL IN’ ON HELPING TRUMP REDISTRICTING PUSH
Trump, in response, repeatedly threatened to back primary challenges against state Republican lawmakers who didn’t support his congressional redistricting push.
«A RINO State Senator, Rodric Bray, who doesn’t care about keeping the Majority in the House in D.C., is the primary problem. Soon, he will have a Primary Problem, as will any other politician who supports him in this stupidity,» Trump warned in a recent social media post.
President Donald Trump, seen pointing as he boards Air Force One at Joint Base Andrews, Maryland, on Sept. 11, 2025, is targeting Indiana Republican lawmakers who are not supportive of the president’s congressional redistricting push. (Mandel Ngan/AFP/Getty Images)
Bray confirmed in a statement last week that the state Senate would return into session to take action on whatever redistricting proposal passes the House.
«The issue of redrawing Indiana’s congressional maps mid-cycle has received a lot of attention and is causing strife here in our state. To resolve this issue, the Senate intends to reconvene as part of the regular 2026 session on Dec. 8,» Bray wrote.
Republicans currently control seven of Indiana’s nine congressional districts, and any new map passed by the GOP supermajority in the legislature would likely shift the state’s 1st Congressional District from blue-leaning to a red-leaning seat.
Trump has been twisting elbows in his attempt to make Indiana the latest Republican-controlled state to change their congressional maps. The president has called state lawmakers and Vice President JD Vance visited the state twice earlier this autumn to discuss redistricting.
TRUMP TARGETS RED STATE REPUBLICAN LAWMAKERS IN PUSH FOR CONGRESSIONAL REDISTRICTING
Trump has also taken some jabs at Republican Gov. Mike Braun of Indiana, arguing that the governor «perhaps, is not working the way he should to get the necessary Votes.»
Indiana Gov. Mike Braun, seen speaking during a press conference on Oct. 30, 2025, supports President Donald Trump’s push for congressional redistricting. (Michael Gard/Post-Tribune/Tribune News Service via Getty Images)
While Trump has called Braun «a good man,» he has warned he «must produce on this, or he will be the only Governor, Republican or Democrat, who didn’t.»
But Braun, pointing to the president, has touted that he is «committed to standing with him on the critical issue of passing fair maps in Indiana to ensure the MAGA agenda is successful in Congress.»
NEWSOM TAKES VICTORY LAP AFTER LANDSLIDE REDISTRICTING VICTORY IN CALIFORNIA
The push by the president in Indiana is part of a broad effort by Trump’s political team and the GOP to pad the party’s razor-thin House majority ahead of the midterms, when the party in power traditionally faces political headwinds and loses seats.
Trump is aiming to prevent what happened during his first term in the White House when Democrats reclaimed the House majority in the 2018 midterm elections.
Texas, Missouri, North Carolina and Ohio have drawn new maps as part of the president’s push. And Florida and Kansas are also mulling redrawing their maps.
«We must keep the Majority at all costs,» Trump wrote recently.
But two federal judges in Texas delivered a blow to Trump and Republicans, by ruling that the state can’t use the newly drawn map in next year’s elections. The Supreme Court put in place a temporary stay on the ruling, ahead of weighing in on the dispute.
Meanwhile, Democrats are fighting back.
California Gov. Gavin Newsom speaks during an election night press conference at a California Democratic Party office Tuesday, Nov. 4, 2025, in Sacramento, Calif. (Godofredo A. Vásquez/AP Photo)
California voters a month ago overwhelmingly passed Proposition 50, a ballot initiative which will temporarily sidetrack the left-leaning state’s nonpartisan redistricting commission and return the power to draw the congressional maps to the Democrat-dominated legislature.
That is expected to result in five more Democratic-leaning congressional districts in California, which would counter the passage earlier this year in Texas of a new map that aims to create up to five right-leaning House seats.
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Illinois and Maryland, two blue states, and Virginia, where Democrats control the legislature, are also taking steps or seriously considering redistricting.
And in a blow to Republicans, a Utah district judge last month rejected a congressional district map drawn up by the state’s GOP-dominated legislature and instead approved an alternate that will create a Democratic-leaning district ahead of the 2026 midterm elections.
donald trump,jd vance,gavin newsom,indiana,midterm elections,house of representatives,republicans elections,elections
La profilaxis preexposición (PrEP) y la profilaxis postexposición (PEP) son estrategias que incluyen a los medicamentos antirretrovirales para prevenir la infección por el virus de la inmunodeficiencia humana (VIH).
En el caso de la PrEP está indicada antes de una exposición potencial al virus, mientras que PEP se emplea tras una situación de riesgo. Ambas buscan evitar que el virus logre establecerse en el organismo humano.
En el marco del Día Mundial del Sida, que se conmemora cada 1° de diciembre desde 1988 con respaldo de las Naciones Unidas, un panel de expertos publicó hoy una guía con recomendaciones y 10 directrices prácticas para facilitar el acceso a PrEP y PEP en adolescentes y adultos que enfrentan situaciones de riesgo.
La guía fue publicada en la revista Canadian Medical Association Journal. Hoy, 40,8 millones de personas viven con el VIH en todo el mundo, 1,3 millones de nuevas infecciones ocurrieron en 2024, y 9,2 millones de personas aún no acceden al tratamiento, según el último reporte del programa Onusida.
A través de la publicación de la guía, se busca desarrollar una prevención más amplia, sencilla y personalizada.
La coordinación estuvo a cargo de Darrell H.S. Tan, infectólogo de St. Michael’s Hospital, en colaboración con el Instituto Canadiense de Investigación en Salud y la Red Pan-Canadiense para Ensayos Clínicos sobre VIH.
Quieren reducir nuevos casos de personas con VIH a través de la prevención combinada y el acceso temprano a opciones farmacológicas.
El objetivo es eliminar obstáculos administrativos y sociales para que quienes pueden beneficiarse con esos tratamientos accedan sin demoras ni requisitos adicionales.
La guía fue diseñada como referencia clara para el personal de la salud y para el público que busca información verificada.
Los autores de la publicación compartieron estas buenas prácticas:
- Ofrecer consejería sobre PrEP y PEP a toda persona sexualmente activa, incluidos adolescentes y usuarios de drogas inyectables, con información positiva.
- Permitir la prescripción de PrEP a cualquier adulto o adolescente que la solicite.
- Evaluar el riesgo de VIH en cada consulta y sugerir PrEP a quienes se puedan beneficiar.
- Si sexo asignado o identidad de género no están claros, el personal de salud se debe guiar para hacer la indicación según la anatomía y situación del paciente y sus parejas.
- Indicar PEP solo ante exposiciones de riesgo real y cuando la persona fuente pueda transmitir VIH.
- Realizar una prueba de VIH antes de dar PEP, sin demorar el tratamiento.
- No prescribir PEP si la persona fuente es VIH negativa, el estatus es desconocido en la población general o la persona con VIH tiene carga viral indetectable.
- En situaciones dudosas, decidir junto al paciente y nunca demorar el acceso a la terapia.
- Comenzar PEP al instante tras la exposición y seguir durante 28 días.
- Se debería involucrar a autoridades, organizaciones y sociedades científicas para promover y monitorear PrEP y PEP.
Los expertos también especificaron que los fármacos que se deberían indicar como PrEP son:
- Tenofovir disoproxil fumarato/emtricitabina: Esquema diario en comprimidos, considerado la opción preferida para la mayoría de las personas VIH negativas.
- Tenofovir alafenamida/emtricitabina: Puede ser considerado en situaciones específicas, por ejemplo, para personas con problemas renales o de densidad ósea.
- Cabotegravir de acción prolongada: Inyección intramuscular cada dos meses. En la guía afirmaron: “Recomendamos CAB-LA 600 mg como opción de PrEP”.
En tanto, los medicamentos para usar en casos de PEP son:
- Bictegravir/tenofovir alafenamida/emtricitabina
- Dolutegravir más tenofovir disoproxil fumarato/emtricitabina
Ambos esquemas deben iniciarse tan pronto como sea posible después de la exposición (máximo 72 horas) y mantenerse durante 28 días.
Esos medicamentos ya demostraron efectividad y seguridad para la prevención del VIH en personas con diferentes perfiles y necesidades, de acuerdo con las recomendaciones actualizadas de la guía.
En diálogo con Infobae, el médico Marcelo Losso, jefe de la sección de enfermedades emergentes e investigador principal de la Unidad de Investigación del Hospital Ramos Mejía y profesor de farmacología de la Facultad de Medicina de la Universidad de Buenos Aires (UBA) en Argentina, comentó sobre la publicación canadiense.
“La nueva guía de manejo de profilaxis pre y posexposición de VIH de Canadá actualiza la recomendación de ofrecer PrEP, siguiendo la posición que previamente habían tomado otros organismos de países de ingresos altos, como los CDC de Estados Unidos y la Asociación Británica de VIH, entre otros. En cambio, la OMS continúa recomendando la estrategia solo en personas de mayor riesgo”, afirmó.
Losso resaltó: “La guía canadiense expande la oferta de PrEP a todos los adolescentes y adultos que lo requieran, independientemente del resultado de su evaluación del riesgo de infectarse”.
La efectividad poblacional de la PrEP, es decir, la capacidad de la estrategia para disminuir el número de nuevos casos, depende principalmente de que una proporción sustancial de quienes la necesitan acceda a su uso.
“Actualmente, una cantidad marginal de individuos recibe PrEP respecto de quienes precisan la estrategia. Esta situación es global, no exclusiva de la Argentina o de otros países de América Latina, y se debe principalmente a la dificultad de implementar medidas preventivas relativamente complejas en población sana”, enfatizó.
El experto añadió: “Implica incorporar al sistema de salud a personas que no necesariamente consultan y luego seguirlas periódicamente, con controles y entrega de medicación. Sin duda, la prioridad actual para nuestros países de la región debería ser la expansión de la implementación de PrEP en poblaciones en riesgo, donde aún mantenemos un déficit significativo”.
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