Two of the Supreme Court’s conservative justices criticized the majority’s decision not to take up attorney Alan Dershowitz’s defamation case against CNN, saying the high court missed an opportunity to revisit a controversial 1960s defamation precedent.

The dissent from the court’s conservative wing effectively called on the justices to revisit longstanding libel precedent, echoing President Donald Trump’s 2016 calls to loosen U.S. libel laws.

Dershowitz, who has represented famous figures like Trump, O.J. Simpson and Leona Helmsley, claimed CNN deceptively edited a snippet of his defense during Trump’s first impeachment trial about «quid pro quo[s]» to make it sound like he said the opposite of his fuller statements and used that clip to damage his reputation.

Justices Clarence Thomas and Neil Gorsuch — appointees of Presidents George H.W. Bush and Trump, respectively — criticized their colleagues for relying on the «actual malice» standard in evaluating whether CNN defamed Dershowitz, arguing the standard is not rooted in the Constitution and instead was created in the Supreme Court’s landmark 1964 decision in New York Times Co. v. Sullivan.

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«Predictably, Dershowitz did not prevail under that exacting standard, which this Court created in New York Times Co. v. Sullivan. Dershowitz now asks this Court to overrule Sullivan and related precedents,» the conservatives wrote.

Dershowitz also reacted to the dissent in remarks to Fox News Digital, calling the majority’s standard «impossible» to overcome.

«All the judges agreed that CNN lied about me,» he said Monday.

«But the majority ruled, over dissents, that I had to prove actual malice by clear and convincing evidence— an impossible standard that I believe will be overruled in years to come.»

The Sullivan case arose after a Montgomery, Alabama, commissioner sued the Times for libel over a full-page advertisement criticizing how the city treated civil rights protesters.

An Alabama jury awarded damages to L.B. Sullivan even though he was not mentioned by name in the ad. The Supreme Court later reversed the ruling, holding that a public official cannot prevail in a defamation case unless he proves the statement was made with «actual malice» — knowing it was false or acting with reckless disregard for the truth.

«The actual-malice standard for public figures bears no relation to the text, history, or structure of the Constitution,» Thomas and Gorsuch wrote Monday in Dershowitz’ case.

«Instead, the founding generation believed that, if anything, public figures had stronger claims for damages when they were defamed.»

As one historical example, Thomas and Gorsuch pointed to the Sedition Act of 1798, which imposed a far lower threshold for defamatory statements about public officials.

Then-Rep. Matthew Lyon, D-Vt., was prosecuted under the law for characterizing President John Adams as someone with «unbounded thirst for ridiculous pomp, foolish adulation and selfish avarice» during American tensions with France.

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President Thomas Jefferson allowed that law to expire in 1801 and pardoned many caught in its net.

More recently, Trump has called for loosening U.S. libel laws, echoing concerns similar to those expressed by Thomas and Gorsuch about the court’s defamation jurisprudence.

While running for president in 2016, Trump pledged to «open up our libel laws» if elected to pursue the ideological conglomerate he often labels «fake news.»

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Journalists who «write purposefully negative and horrible and false articles — we can sue them and win lots of money,» Trump said.

He has often singled out defendant CNN more than most – famously warring regularly with its then-White House correspondent, podcaster Jim Acosta.

During one 2017 incident, Acosta repeatedly interrupted Trump during a news conference, leading the president to demand he not «be rude.».» Trump informed Acosta that he would not be taking a question from him because «you are fake news.»

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«We’re going to open up libel laws, and we’re going to have people sue you like you’ve never got sued before,» Trump said at the 2016 event, going on to further name-drop the Times and Washington Post.

The ruling, along with Trump’s own lawsuit against the Ted Turner-founded network over its use of the term «Big Lie» to describe his claims about the 2020 election, leaves open the possibility that the court could revisit Sullivan, though such a shift appears unlikely in the near term.

Fox News Digital reached out to CNN for comment on the dissent.

Científicos de los Estados Unidos descubrieron que una proteína cerebral llamada Arc transporta la Tau tóxica, la sustancia que destruye neuronas en Alzheimer, desde células enfermas a células sanas y acelera así el avance de la enfermedad.

El hallazgo, publicado en la revista Cell, puede cambiar la forma de entender cómo progresa el Alzheimer y abre una vía para frenarlo.

Ese trastorno es la forma más frecuente de demencia: destruye las neuronas del cerebro de manera progresiva y afecta la memoria, el lenguaje y la capacidad de realizar tareas cotidianas.

La proteína Tau, que en condiciones normales ayuda a mantener la estructura interna de las neuronas, se deforma en esta enfermedad, se vuelve tóxica y forma grumos que matan las células.

Se estima que más de 55 millones de personas viven con demencia en el mundo, según la organización Alzheimer’s Disease International (ADI). Alzheimer representa cerca del 70% de esos casos.

Arc: el mensajero con un pasajero clandestino

Arc tiene una función normal y vital: empaqueta información dentro de pequeñas burbujas llamadas vesículas extracelulares —algo así como sobres microscópicos— y las envía de neurona en neurona. El problema surge cuando la Tau tóxica se cuela dentro de esos “sobres” y viaja con ellos hacia células que aún están sanas.

Mitali Tyagi, investigadora de la Universidad de Washington en St. Louis y primera autora del estudio, comparó las acumulaciones de Tau con “monstruos de pegamento” porque, “se pegan entre sí y bloquean el transporte dentro de la neurona”.

Pero también se fragmentan en piezas menores que migran a nuevas células y corrompen la Tau sana que encuentran allí.

El equipo comparó ratones con Alzheimer que tenían Arc con ratones que carecían de ella. En los segundos, las vesículas extracelulares contenían apenas rastros de Tau tóxica y ya no podían dañar neuronas sanas.

“Cuando eliminamos Arc, vimos que la transferencia de Tau se redujo de manera drástica. Casi desapareció”, afirmó la científica.

Arc presenta un dilema: aunque facilita el avance de la enfermedad, también protege a las neuronas enfermas en etapas tempranas al expulsar el exceso de Tau hacia afuera. Sin esa válvula de escape, las células enfermas mueren más rápido.

Eliminar Arc de raíz, entonces, no sería la solución. El equipo apunta a algo más preciso: interceptar las vesículas con Tau tóxica después de que salen de la neurona enferma, pero antes de que lleguen a una sana.

Esa ventana —entre la expulsión y la infección— es donde los investigadores ven la mayor oportunidad terapéutica.

Ahora se sabe que Arc cumple un papel doble: propaga la enfermedad pero también protege a las neuronas enfermas en etapas tempranas. El gran desafío es cómo diseñar una terapia que bloquee su efecto dañino sin eliminar su función protectora.

Desde los Estados Unidos, el doctor Jason Shepherd, profesor de neurobiología de la Universidad de Utah y autor principal del estudio, contestó a Infobae: “Creemos que la clave está en intervenir sobre el momento en que las neuronas vecinas absorben la Tau que viene dentro de las vesículas extracelulares. Si logramos bloquear esa absorción, las células enfermas seguirían expulsando su exceso de Tau —y así se protegerían— pero la Tau tóxica ya no podría entrar en las células sanas. Eso detendría la propagación sin eliminar el efecto protector de Arc».

Para pacientes con Alzheimer en etapa temprana, detener ese tráfico podría frenar el deterioro cognitivo futuro.

Una terapia de ese tipo no repararía el daño ya existente en el cerebro, pero podría evitar que la enfermedad avance hacia nuevas regiones. Para millones de pacientes en etapas iniciales, eso marcaría una diferencia real.

¿En qué plazo realista podría traducirse ese enfoque en un tratamiento para pacientes con Alzheimer en etapa temprana?, preguntó Infobae al doctor Shepherd. “Sí, esa es exactamente la idea. Todavía hay mucho por resolver y la mayor parte de este trabajo se realizó en ratones. El próximo paso es trabajar con células humanas y, a partir de ahí, avanzar hacia el desarrollo de fármacos. Ese camino llevará tiempo”, contestó.

El equipo también encontró vesículas con Arc y Tau en tejido cerebral humano, una pista de que el mecanismo podría operar de forma similar en personas.

Shepherd fue cauteloso al respecto: “La mayor parte del trabajo lo hemos hecho en ratones, no en humanos. Tenemos algunas pistas, pero aún no lo sabemos con certeza”.

En diálogo con Infobae, el doctor Ricardo Allegri, investigador del Conicet, jefe de neurología cognitiva de Fleni y director de la carrera de posgrado de Psicología con Orientación en Neurociencia de la Universidad Maimónides (UMAI), comentó sobre el nuevo estudio publicado en Cell.

“La hiperfosforilación de la proteína Tau desestabiliza los microtúbulos y lleva a la muerte neuronal. La patología Tau está directamente relacionada con la sintomatología del Alzheimer, a diferencia de la patología amiloide, que no lo está”, aclaró.

“Ya sabíamos que la Tau patológica se contagia de neurona a neurona siguiendo los circuitos funcionales neuronales. Pero no conocíamos cómo pasaba de una neurona a otra. El nuevo estudio aporta resultados en esa dirección”, resaltó.

“La proteína Arc interviene en la formación de las vesículas y en su volcado. Este hallazgo es sumamente importante porque, si podemos intervenir sobre este mecanismo, podríamos frenar el avance de la enfermedad y sus síntomas”, sostuvo el doctor Allegri.

El estudio contó con financiamiento de los Institutos Nacionales de Salud (NIH), la Asociación de Alzheimer y la Iniciativa Chan-Zuckerberg, entre otras organizaciones.

Detectar la enfermedad en sus primeras etapas es la mejor forma de actuar antes de que el daño se extienda. Las señales de alerta más frecuentes son la pérdida de memoria reciente, la dificultad para encontrar palabras, la desorientación en lugares conocidos y los cambios repentinos de humor o personalidad.

Ante esos síntomas, la recomendación de los especialistas es consultar a un médico clínico o neurólogo sin demora.

Un diagnóstico temprano permite iniciar tratamientos que, aunque no curan la enfermedad, pueden ralentizar su progresión y mejorar la calidad de vida del paciente y su entorno.

California state Sen. Scott Wiener, D-San Francisco, was widely mocked by conservatives on social media over two videos of him being shouted down by anti-Israel activists in his own district over his stance on Israel, despite his progressive track record.

The first video showed several people surrounding Wiener, running for Congress to replace Speaker Emerita Nancy Pelosi, as he walked through San Francisco’s Trans March at Dolores Park on Friday, with multiple hecklers shouting profanity-laced insults.

«We f—ing hate you!» Wiener was told in the video that was viewed over 11 million times on X, posted by Dimitry Yakoushkin, who could be heard criticizing Wiener’s position on the war in Gaza as the Democratic lawmaker moved away from the crowd. 

Conservatives on social media widely mocked Wiener and pointed to the fact that he is considered one of the most progressive Democrats in the country and yet was still attacked by his own constituency for not being critical enough of Israel.

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«No one more richly deserves this humiliation than Scott Wiener, who learns the hard lesson that you can be a militant for trans radicalism, a full-scale Israel-hater, and an all-around moral derelict…and the hard Left will still yell at you for being a Jew,» conservative commentator Ben Shapiro posted on X. «10/10, no notes.»

«Hey, Wiener guy!» Reality TV star and former Los Angeles mayoral candidate Spencer Pratt posted on X. «Remember when you called me a ‘McBigot’? How does it feel now that the Frankenstein you created is coming for you? Every stupid communist learns this history lesson the hard way. Enjoy!»

«I have zero sympathy for eat me last Democrats like Wiener who enabled anti-white bigotry to fester, threw open our borders to foreigners with alien ideologies, and poured gasoline on the dumpster fire of the trans contagion and LGBTQ insanity,» Charlie Kirk Show executive producer Andrew Kolvet posted on X. 

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«The left deserves itself,» political commentator Tim Pool posted on X.

Wiener, who is gay and Jewish, was also the target of a second incident last Wednesday that went viral, when he was harassed at a San Francisco bar over Israel as he attempted to watch a World Cup game.

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State Sen. Scott Wiener of California, who previously refrained from calling Israel’s actions in Gaza a «genocide,» reversed course in January. (Sen. Scott Wiener/California Senate)

«For the Jews thinking you can play footsie with these people… they just hate you because you’re a Jew,»  XX-XY Athletics founder and CEO Jennifer Sey, posted on X. «That’s it. That’s what it comes down to. Wiener is Jewish. Never bend a knee. It won’t go well.»

«Once they’re done with Zionism, they’ll come after democracy, capitalism, and the foundation of Western society and government,» Hussain Abdul-Hussain, research fellow at the Foundation for Defense of Democracies, posted on X. 

«Palestine is the tip of the iceberg. The iceberg is ‘Islam is the solution,’ the alternative to Enlightenment ideas, as imagined by Muslim Brotherhood ideology.»

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California state Sen. Scott Wiener participates in the 54th Annual San Francisco Pride Parade on June 30, 2024, in San Francisco, Calif. (Miikka Skaffari/Getty Images)

«You can see the fear in his eyes, and while I have little in common with him, there is something relatable about this moment,» California Post opinion editor Joel Pollak posted on X. «It’s no real consolation to point out that he tried appeasing the hatred (letting the rest of us be victimized). This is what we look like before the end.»

Wiener’s office released a lengthy statement about the two incidents, posting online that Wiener was «harassed, threatened, and physically intimidated while attending public events to engage with the San Francisco community.»

«I have no objection whatsoever to anyone disagreeing with me, opposing me, or protesting me,» Wiener said in the statement. «All of that is core to democracy. I also have no issue when people talk to me on the street and ask questions or express opposition. That’s democracy, even when the people engaging in this conduct misrepresent my views.»

«But when opposition and disagreement transition to harassment, including cornering me, touching me, or trying to physically bully me out of a public event, that crosses a line.  We’re living in a time when violence is all too often threatened or used against people in public life. In San Francisco, we’re better than that.» 

Wiener, who had previously stopped short of using the word «genocide,» reversed course in January and said he believed Israel’s actions in Gaza qualified as genocide. The California Post editorial board commented on the shift in a recent piece ,saying, «The irony: It wasn’t enough,» the outlet wrote. «Nothing is ever enough. Wiener remains a target, even though he changed his mind, because he is Jewish.»

Fox News Digital’s CJ Womack contributed to this report.